Ribonucleotide Reductase Inhibition Enhances Chemoradiosensitivity of Human Cervical Cancers
نویسندگان
چکیده
منابع مشابه
Inhibition of ribonucleotide reductase activity by IC202C.
suppresses DNAsynthesis by inhibition of ribonucleotide reductase.4) Ribonucleotide reductase plays an essential role in DNAsynthesis in most organisms.5) The enzyme is a nonheme iron-containing protein, which requires ATPand Mg2+ as co factors. As previously reported that IC202C has art affinity against Fe(III) ion,3) we have examined the effect of IC202C on ribonucleotide reductase activity u...
متن کاملPreventive and Therapeutic Vaccines against Human Papillomaviruses Associated Cervical Cancers
Cervical cancer is, globally known to be, one of the most common cancers among women especially indeveloping countries. More than 90% of cervical cancers are associated with high-risk humanpapillomaviruses (HPVs) particularly HPV types 16 and 18. Two major strategies have been developed forprevention and treatment of cervical cancer and other HPV-associated malignancies; the first one is based ...
متن کاملHydroxyurea-Mediated Cytotoxicity Without Inhibition of Ribonucleotide Reductase
In many organisms, hydroxyurea (HU) inhibits class I ribonucleotide reductase, leading to lowered cellular pools of deoxyribonucleoside triphosphates. The reduced levels for DNA precursors is believed to cause replication fork stalling. Upon treatment of the hyperthermophilic archaeon Sulfolobus solfataricus with HU, we observe dose-dependent cell cycle arrest, accumulation of DNA double-strand...
متن کاملInhibition of Ribonucleotide Reductase from Ehrlich Tumor Cells by RNA1
oncogenic RNA viruses. It has also been reported (24) that single-stranded polyribonucleotides at very low concentrations inhibit DNA polymerase of Rauscher leukemia virus. In this report, we present data that show a way in which RNA indirectly affects DNA synthesis. These data show that RNA markedly inhibits ribonucleotide reducÃ-asefrom Ehrlich ascites tumor cells, at concentrations which cou...
متن کاملInhibition of ribonucleotide reductase from Ehrlich tumor cells by RNA.
oncogenic RNA viruses. It has also been reported (24) that single-stranded polyribonucleotides at very low concentrations inhibit DNA polymerase of Rauscher leukemia virus. In this report, we present data that show a way in which RNA indirectly affects DNA synthesis. These data show that RNA markedly inhibits ribonucleotide reducÃ-asefrom Ehrlich ascites tumor cells, at concentrations which cou...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Radiation Research
سال: 2010
ISSN: 0033-7587,1938-5404
DOI: 10.1667/rr2273.1